欢迎来到抗癌健康网!  
放入收藏夹 | pc蛋蛋助赢软件

pc蛋蛋:绿茶成分有助抵御艾滋病病毒

pc蛋蛋助赢软件 www.ez4a.com.cn 2018-04-25

抗癌健康网

手机看网页

导读:英美科学家通过联合研究发现,绿茶所含的一种成分能阻止艾滋病病毒附着到免疫细胞上。

  英美科学家通过联合研究发现,绿茶所含的一种成分能阻止艾滋病病毒附着到免疫细胞上。

  据英国媒体31日报道,研究人员发现,绿茶含有一种多酚类化合物EGCG,一旦这种成分先附着在免疫细胞上,艾滋病病毒就不再有机会附着上去了。

  英国谢菲尔德大学的威廉姆森教授说:“我们的研究显示,喝绿茶可能有助于减少感染艾滋病病毒的危险,并有助于减缓艾滋病病毒的扩散。”

  但他同时强调说,喝绿茶不是治疗艾滋病的方法,也不是预防艾滋病的安全手段,但对一些感染者来说,这种方法可以与传统药物相配合,缓解他们的病情。

  威廉姆森说,有关的研究还处于初级阶段,还要进一步研究,看绿茶饮用量是否影响绿茶成分抵御艾滋病病毒的效果。

  这项联合研究成果刊登在最新一期美国《过敏与临床免疫学》杂志上。

  部分英文原文:

  Volume 113, Issue 2 (Supplement), Page S256 (February 2004)

  Green tea polyphenol epigallocatechin gallate binding to CD4 as a model for the inhibition of HIV-1-gp120 binding to CD4+ T cells

  Abstract

  Rationale

  The catechin, epigallocatechin gallate (EGCG), the active component of green tea, has anti-inflammatory, anti-tumorigenic, and anti-oxidative as well as anti-viral properties. In vitro, EGCG inhibits HIV-1 replication by the inhibition of HIV-1 reverse transcriptase with a resultant lowered p24 antigenemia. Recently, EGCG has been linked with interference of gp120 binding to CD4. We propose a model of EGCG binding to the CD4 molecule with competitive inhibition of HIV-1-gp120 binding.

  Methods

  Previously generated NMR spectroscopy and time-averaged nuclear Overhauser effects of EGCG protein chemistry were utilized in the development of multiple EGCG molecular conformations. Using the protein database file 1CDJ, the molecular structure of CD4 was illustrated via electron density mapping at 3A. Modeling of EGCG binding to CD4 was achieved by computer-generated docking programs.

  Results

  Specific residues of the D1 domain of the CD4 molecule involved in HIV-1-gp120 binding were demonstrated to be potential sites of EGCG binding. Analysis of the residues involved in the binding of HIV-1-gp120 to the CD4 molecule revealed a binding pocket of amino acids, flanked by Phe43 and Arg59. The inherent conformational flexibility of EGCG lends itself to binding with this region of critical residues.

  Conclusions

  Mechanisms that interfere with the interaction of HIV-1-gp120 and CD4+ T cells have been purported as potential targets in HIV-1 treatment. We present a model of EGCG binding to a pocket of the CD4 molecule that might result in the interference of HIV-1-gp120 binding and subsequent inhibition of HIV-1 infection of CD4+ T cells.

[关键词: 绿茶 艾滋病病毒 ]

在这里,掌握健康资讯

扫描左侧二维码即可添加抗癌健康网官方微信;
健康之路 与你同行
肠癌更多>>
肠癌是胃肠道中常见的恶性肿瘤,发病率仅次于胃和食管癌,是大肠癌的最常见部分(占60%左右)。[详情]
热文欣赏更多>>

健康阅读

推荐欣赏

  • 热门推荐
  • 最新期刊
  • 疾病关注
长期憋尿,膀胱癌,长期憋尿引发膀胱癌
[详情]
白血病与骨髓移植术
[详情]
筷子致癌?靠什么吃饭?
[详情]
卵巢囊肿并不可怕
[详情]
调理内分泌多吃黄色食物
[详情]
吃腐乳致癌可信吗?
[详情]
资讯排行榜更多>>
肺癌康复指南吃什么?
信息聚焦更多>>
化疗药物中成药止痛药
卡铂珍香胶囊阿司匹林
顺铂参丹散结胶囊扑热息痛
5-氟尿嘧啶食道平散盐酸哌替啶片
西妥昔单抗抗癌平丸吗啡
多柔比星志苓胶囊芬太尼
视频推荐更多>>
肿瘤热文欣赏更多>>

特别声明:本站信息仅供参考 不能作为诊断及医疗的依据平台联系我们

抗癌健康网 版权所有 未经授权请勿转载  CopyRight?2008-2018 pc蛋蛋助赢软件 www.ez4a.com.cn, All Rights Reserved. 浙ICP备11014848号

264| 429| 645| 663| 798| 120| 105| 846| 573| 377|